SYSTEMATIC EXPRESSION ANALYSIS OF LIGAND-RECEPTOR PAIRS REVEALS IMPORTANT CELL-TO-CELL INTERACTIONS INSIDE GLIOMA

Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside glioma

Abstract Background Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults.Traditional researches mainly explored the expression profile of glioma at cell-population Dice level, but ignored the heterogeneity and interactions of among glioma cells.Methods Here, we firstly analyzed the single-cell RNA-seq (scRNA-seq) da

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